Polynucleotides (PNs) are biocompatible and naturally derived molecules increasingly used in aesthetic medicine for skin rejuvenation, tissue regeneration, and hair restoration. They comprise nucleotides building blocks of DNA and RNA and function as powerful bio-stimulants, aiding in cell repair and regeneration.

What Are Polynucleotides?

Polynucleotides are chains of nucleotides linked together, extracted primarily from natural sources like salmon sperm DNA, which closely resembles human DNA in its structure. These molecules are processed for medical and cosmetic use to ensure safety and effectiveness. They are known for their excellent ability to retain water, promote healing, and stimulate the skin’s natural repair mechanisms.

Applications in Skin and Hair Treatments

1. Skin Rejuvenation

Polynucleotides are used to treat a variety of skin concerns, including:

  • Fine lines and wrinkles: By stimulating fibroblast activity, they encourage the production of collagen and elastin.
  • Skin hydration: Their high water-binding capacity helps restore moisture and improve skin texture.
  • Scarring and pigmentation: Polynucleotides enhance wound healing and reduce post-inflammatory hyperpigmentation, making them effective for acne scars and other marks.
  • Sensitive or damaged skin: They improve the skin barrier, reduce redness, and enhance skin health in conditions like rosacea.

How It Works: Polynucleotides improve skin elasticity and hydration by:

  • Stimulating collagen synthesis for structural support.
  • Reducing oxidative stress by neutralizing free radicals.
  • Promoting angiogenesis (formation of new blood vessels), improving microcirculation and nutrient delivery to the skin.

2. Hair Restoration

Polynucleotides are increasingly utilized to treat hair loss conditions, such as androgenetic alopecia or telogen effluvium. Their regenerative and anti-inflammatory properties help:

  • Revitalize hair follicles.
  • Stimulate hair growth by enhancing blood flow to the scalp.
  • Repair and strengthen the scalp’s skin, creating a healthy environment for hair growth.

How It Works: Polynucleotides activate dermal papilla cells (key to hair follicle health) and improve oxygenation and nutrient delivery to the hair roots. They also help regulate inflammatory pathways, which are often linked to hair thinning or loss.

Combination Treatments with Polynucleotides

Polynucleotide treatments can be combined with other modalities for enhanced results:

  • Microneedling: Boosts the penetration and absorption of polynucleotides for deeper skin repair and hair follicle stimulation.
  • Chemical Peels: Prepares the skin for polynucleotide application by removing dead skin cells.
  • Mesotherapy: Injecting polynucleotides into the dermis for targeted skin and scalp rejuvenation.
  • LED Light Therapy (Comes as standard) to further boost collagen.

Benefits of Polynucleotide Treatments

  1. Improved Elasticity: Boosts the skin’s firmness and reduces sagging.
  2. Deep Hydration: Retains moisture for a plump, youthful appearance.
  3. Tissue Repair: Accelerates the healing of damaged skin and scalp tissue.
  4. Minimal Downtime: Non-invasive or minimally invasive with quick recovery.
  5. Anti-inflammatory Effects: Reduces redness and irritation, making it suitable for sensitive skin types.
  6. Hair Follicle Stimulation: Promotes stronger, healthier hair growth.

What to Expect During the Procedure

  1. Consultation: Skin or hair is assessed to determine suitability for polynucleotide treatment.
  2. Preparation: The area is cleansed, and a numbing cream may be applied for comfort.
  3. Application:
    • Skin: Polynucleotides are injected into the dermis using fine needles or applied topically after microneedling.
    • Hair: Microinjections are made into the scalp to deliver the product directly to hair follicles.
  4. Aftercare: Patients are advised to avoid excessive sun exposure, makeup, or strenuous activity for 24-48 hours.

Side Effects and Safety

Polynucleotide treatments are generally safe, with minimal side effects due to their biocompatibility. Mild swelling, redness, or bruising at the injection site may occur but typically resolves within a few days. As polynucleotides are derived from natural sources, the risk of allergic reactions is minimal.

Who Can Benefit?

Polynucleotides are suitable for individuals experiencing:

  • Dry, dull, or ageing skin.
  • Fine lines, wrinkles, or loss of elasticity.
  • Scarring or pigmentation issues.
  • Hair thinning or early-stage hair loss.

Results and Maintenance

  • Skin Treatments: Improvements in hydration, elasticity, and tone are noticeable within 2-4 weeks. A series of 3-4 sessions spaced a few weeks apart is typically recommended.
  • Hair Treatments: Results, such as reduced hair fall and visible growth, are seen after 2-3 months, with maintenance sessions every 6-12 months.

Conclusion

Polynucleotides offer a scientifically-backed, versatile solution for skin rejuvenation and hair restoration. Whether used alone or in combination with other treatments, their regenerative properties make them a popular choice for achieving radiant skin and healthy hair.

Frequently Asked Questions (FAQs) 

1. What are polynucleotides?

Polynucleotides are natural molecules made from DNA fragments that promote skin and tissue repair, enhance hydration, and stimulate collagen production. They are derived from safe, biocompatible sources like salmon DNA.

2. What can polynucleotide treatments help with?

Polynucleotide treatments are effective for:

  • Reducing fine lines and wrinkles.
  • Improving skin hydration and elasticity.
  • Treating scars, including acne scars.
  • Rejuvenating dull or damaged skin.
  • Stimulating hair growth and reducing hair thinning.

3. How do polynucleotides work?

Polynucleotides work by:

  • Stimulating the production of collagen and elastin to improve skin texture and elasticity.
  • Enhancing skin hydration by retaining moisture.
  • Promoting tissue regeneration and improving blood flow.
  • Supporting hair follicles and scalp health for hair restoration.

4. Are polynucleotide treatments safe?

Yes, polynucleotide treatments are very safe. They are biocompatible and derived from natural sources, with minimal risk of allergic reactions. Mild side effects like redness or swelling may occur but typically subside quickly.

5. How many sessions are required?

For optimal results:

  • Skin treatments: A series of 3-4 sessions spaced 2-4 weeks apart is recommended.
  • Hair treatments: Typically, 4-6 sessions over a few months, followed by maintenance sessions every 6-12 months.

6. Is there any downtime?

Polynucleotide treatments are minimally invasive with little to no downtime. Some redness, swelling, or bruising may occur at the injection site but usually resolves within 24-48 hours.

7. Can polynucleotides be combined with other treatments?

Yes, polynucleotides work well with:

  • Microneedling: Enhances absorption for deeper skin repair.
  • Chemical Peels or Lasers: Prepare the skin for better results.
  • Mesotherapy: Delivers polynucleotides directly into the skin or scalp.

8. How soon will I see the results?

Results vary by individual:

  • Skin treatments: Improvements in hydration, elasticity, and texture can be seen within 2-4 weeks.
  • Hair treatments: Reduced hair loss and initial growth are noticeable after 2-3 months.

9. Who is a good candidate for polynucleotide treatments?

These treatments are suitable for individuals with:

  • Dry, dull, or ageing skin.
  • Fine lines, wrinkles, or sagging skin.
  • Scars, pigmentation, or redness.
  • Hair thinning or early-stage hair loss.

10. How long do the results last?

With proper care, results can last:

  • Skin treatments: 6-12 months, depending on lifestyle and skincare routine.
  • Hair treatments: Maintenance sessions every 6-12 months help sustain hair growth.

11. Are polynucleotide treatments painful?

The treatment is generally well-tolerated. A numbing cream may be applied before the procedure to ensure comfort.

12. Are there any side effects?

Common side effects include:

  • Temporary redness, swelling, or mild bruising at the injection site.
  • Rarely, slight itching or sensitivity. These resolve quickly.

13. Can polynucleotide treatments be used for sensitive skin?

Yes, polynucleotides are suitable for sensitive or reactive skin, as they help improve the skin barrier and reduce inflammation.

 

15. How do I prepare for the treatment?

  • Avoid alcohol, aspirin, or anti-inflammatory medications 24 hours before the procedure.
  • Ensure the treatment area is clean and free from makeup or products.

 

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